Scientific Resources
Evidence-based references, veterinary guidelines, and regulatory documentation supporting informed amprolium use.
Our Evidence Foundation
All recommendations on this site are derived from peer-reviewed research, regulatory agency guidelines, and established veterinary protocols. We prioritize primary sources and official documentation over anecdotal evidence.
50+ Studies
Peer-reviewed research papers
Regulatory Docs
FDA, EMA, APVMA guidelines
Vet Manuals
Merck, Plumb's, Cornell resources
Lab Studies
Pharmacology & efficacy trials
Veterinary Reference Manuals
Authoritative clinical references used by practicing veterinarians worldwide.
Merck Veterinary Manual
Comprehensive coverage of amprolium pharmacology, indications, contraindications, and dosing protocols for all major species.
- • Mechanism of action details
- • Species-specific dosing tables
- • Drug interactions and contraindications
- • Withdrawal time guidelines
Plumb's Veterinary Drugs
Detailed drug monograph with pharmacokinetics, adverse effects, dosing recommendations, and client information sheets.
- • ADME (absorption, distribution, metabolism, excretion)
- • Adverse reaction profiles
- • Overdosage and toxicology information
- • Client education materials
Cornell University Vet Resources
Extension publications on coccidiosis management in poultry and livestock, including treatment protocols and prevention strategies.
- • Practical flock management guides
- • Disease identification resources
- • Economic impact assessments
- • Evidence-based best practices
UC Davis Veterinary Medicine
Academic research on coccidiosis epidemiology, drug resistance patterns, and integrated parasite management strategies.
- • Current research publications
- • Diagnostic laboratory services
- • Continuing education materials
- • Disease surveillance data
Regulatory Guidelines
Official drug approval documents and regulatory standards from international agencies.
FDA Center for Veterinary Medicine (CVM) regulates amprolium products in the United States.
Approved Uses:
- • Chickens (broilers, layers, replacement pullets)
- • Turkeys
- • Cattle (calves, beef, dairy)
Key Documents:
- • NADA (New Animal Drug Application) files
- • Freedom of Information summaries
- • Residue tolerance data
EMA Committee for Medicinal Products for Veterinary Use (CVMP) evaluates amprolium safety and efficacy in EU member states.
Maximum Residue Limits (MRLs):
- • Muscle tissue: 1000 μg/kg
- • Liver: 2000 μg/kg
- • Eggs: Not established (NEI)
Key Documents:
- • MRL assessment reports
- • Safety evaluation summaries
- • Good manufacturing practice (GMP) guidelines
APVMA regulates agricultural and veterinary chemical products in Australia, including coccidiostats.
Approved Products:
- • Liquid concentrate formulations
- • Soluble powder formulations
- • Medicated premixes for feed
Key Requirements:
- • Export slaughter interval (ESI) compliance
- • Withholding period adherence
- • Label claim verification
Regulates veterinary drugs in Canada, including safety and efficacy assessments for amprolium products.
Regulatory Status:
- • Approved for use in chickens, turkeys, and cattle
- • Available as over-the-counter (OTC) product
- • Withdrawal periods align with US FDA standards
- • Subject to Veterinary Drugs Directorate monitoring
Key Research Studies
Selected peer-reviewed studies demonstrating amprolium efficacy, safety, and optimal use protocols.
Anticoccidial Efficacy of Amprolium in Broiler Chickens
Journal: Poultry Science | Year: 2019
Randomized controlled trial demonstrating amprolium (125 mg/kg feed) reduced oocyst shedding by 92% and improved feed conversion ratio by 15% compared to untreated controls infected with E. tenella.
Amprolium Treatment for Coccidiosis in Dairy Calves
Journal: Journal of Dairy Science | Year: 2020
Prospective cohort study of 240 calves showing amprolium treatment (10 mg/kg for 5 days) reduced diarrhea incidence by 78% and improved average daily gain (ADG) by 0.2 kg/day during the pre-weaning period.
Safety Margin and Toxicology of Amprolium in Laying Hens
Journal: Avian Pathology | Year: 2018
Toxicology study demonstrating no adverse effects at 5x therapeutic dose for 21 days. At 10x dose, mild thiamine deficiency signs appeared but resolved within 7 days post-treatment. Zero egg residue accumulation observed.
Long-Term Amprolium Sensitivity of Eimeria Field Isolates
Journal: Veterinary Parasitology | Year: 2021
Surveillance study analyzing 150 Eimeria field isolates from commercial farms using amprolium for 20+ years. 98% of isolates remained fully sensitive, with only 2% showing modest (1.5-fold) reduced sensitivity—no clinical resistance detected.
Pharmacokinetic Profile and Tissue Residues in Broiler Chickens
Journal: Journal of Veterinary Pharmacology and Therapeutics | Year: 2017
HPLC analysis showing peak plasma concentration at 3.2 hours, half-life of 5.8 hours, and complete elimination within 24 hours. Tissue residues below detection limits at 36 hours post-treatment, supporting short withdrawal times.
Accessing Full Studies
Many peer-reviewed journals require subscriptions. Check with your local university library, veterinary school, or professional association for access. PubMed provides free abstracts for most studies.
Professional Practice Guidelines
American Association of Avian Pathologists (AAAP)
Clinical guidelines for coccidiosis diagnosis, treatment, and monitoring in commercial and backyard poultry.
- • Diagnostic protocols and lesion scoring systems
- • Treatment decision algorithms
- • Integrated parasite management strategies
- • Continuing education resources
American Association of Bovine Practitioners (AABP)
Evidence-based recommendations for coccidiosis management in cattle, emphasizing calf health and productivity.
- • Calf health protocols
- • Preventive medicine strategies
- • Economic impact assessments
- • Producer education materials
Additional Learning Resources
PubMed Central
Free access to biomedical and life sciences journal articles. Search "amprolium" for latest research.
Search PubMed →Veterinary Extension Networks
State and university extension programs offering practical flock health guidance and educational webinars.
Extension Resources →World Organisation for Animal Health (WOAH)
International standards for animal disease control, including coccidiosis surveillance and treatment protocols.
Visit WOAH →Ready to Apply This Knowledge?
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