The Science Behind the Solution
Amprolium exploits the parasite’s addiction to thiamine. Because Eimeria cannot synthesize vitamin B1, it must import it from the host’s gut. Amprolium’s similar structure lets it “sit” in the transporter, blocking real thiamine.
Lifecycle in Brief
- Ingestion: Birds pick up sporulated oocysts from litter.
- Excystation: Sporozoites invade gut lining, consuming thiamine.
- Replication: Multiple rounds of asexual reproduction damage villi.
- Shedding: New oocysts exit in droppings, restarting the cycle.
By out‑competing thiamine, Amprolium stalls replication inside the gut, allowing the host to clear the infection naturally.
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